Latest news about H5N1 resistance to Tamiflu® points to a combined zanamivir/oseltamivir strategy including Relenza

Etopia Media Medical News Network #102/ Tamiflu® World #4

Los Angeles, California
October 15, 2005

By Marc Strassman
Reporter
Tamiflu® World
Etopia Media Medical News Network
Etopia Media News Networks

This page and its contents are copyright © 2005 by Etopia Media News Networks. All rights in all media reserved.

Roche Pharmaceuticals Tamiflu® capsule and packaging


Strategies for dealing with a possible global avian flu pandemic brought about by the H5N1 virus seem to be evolving at viral speeds as mankind faces off against this semi-living entity.


the latest H5N1 news

For the latest in detailed coverage of this epic struggle, as reported in an article entitled "Further reports of Tamiflu resistance in avian flu virus pending: expert," published Saturday, October 15, 2005, on the canada.com Health site, click here.

coy, partial disclosures from the University of Virginia

This article features some sly talk from Dr. Frederick Hayden, "a professor of clinical virology at the University of Virginia, …[and] co-chair of an international scientific group that closely monitors for emergence of viral resistance to neuraminidase inhibitors - the drug class to which Tamiflu belongs," in which he drops some hints about the number of cases where H5N1 was not affected by Tamiflu.

a two-pronged approach may be necessary to stop H5N1 (for now)

The article concludes by saying that while the strain of bird flu in the most-prominent case in Vietnam seems to be resistant to oseltamivir (the active ingredient in Tamiflu®) it is very susceptible (so far) to zanamivir (the active ingredient in Relenza).

Asian, Turkish, and Romanian avian flu viruses are the same H5N1 strain

Another article on the canada.com web site worth looking at is called Bird flu found in Romania is same deadly strain as detected in Asia, Turkey".

Yea, though I walk through the valley of the shadow of death…some things don't change

As referenced in a previous Tamiflu® World article "Roche declines to comment, as Indian drug company announces its plans to produce a generic version of Roche's patented anti-viral Tamiflu®" and as shown by Dr. Hayden's reluctance to divulge everything he knows in a way that would interfere with scientific publication protocols, there is still a place for commercial and academic competition, even under the cloud of an impending global influenza pandemic.

mechanisms of anti-viral action explained by the Medical Director of Roche Pharmaceuticals, current owners of the Tamiflu® franchise

To learn about how anti-virals work to limit the ability of viruses to self-propagate by hi-jacking the reproductive machinery in cells, making hundreds of thousands of copies of themselves, splitting the cell open and repeating the process enough times to sicken or kill their victims, listen to Dr. Dominick Iacuzio, Medical Director at Roche Pharmaceuticals, explains how anti-virals such as Tamiflu® work and how they can provide a more reliable defense against a possible avian influenza pandemic than a strategy relying on vaccination, first published on the Etopia Media Medical News Network on November 3, 2004.

 



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